The South Slave Region of the Northwest Territories has long been overlooked in archaeological research and consequently contains a low overall density of recorded archaeological sites and a poorly understood culture-history. However, the Hay River delta, south shore of Great Slave Lake, Buffalo River and Buffalo Lake represent an extraordinarily rich cultural landscape within Kátł’odeeche First Nation (KFN) territory. This paper will present preliminary results of the work  conducted by KFN and the Prince of Wales Northern Heritage Centre to investigate the antiquity of a significant seasonal travel route in this area, as well as the series of fish camps, gathering places and settlements along the route that figure prominently in KFN Elder’s experiences.